Recombinant human VSIG4 protein   

V-set and immunoglobulin domain-containing protein 4; CRIg; V set and immunoglobulin domain containing 4; Z39IG; VSIG4_HUMAN.  

濃度：1mg/ ml

來(lái)源：Recombinant Human

純度：≥95% SDS-PAGE

表達(dá)系統(tǒng)：HEK 293 cells

標(biāo)簽：His tag C-Terminus   

蛋白長(zhǎng)度：Full length protein

內(nèi)毒素水平：<1.000 Eu/µg

純化方法：HPLC

應(yīng)用：SDS-PAGE，Western blot，ELISA

Biological activity,immunology research

保存：-20℃

保質(zhì)期：1年

T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 familyrelated protein V-set and Ig domaincontaining 4 (VSIG4). Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th celldependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.

產(chǎn)品名稱：Rabbit Anti-VSIG4 protein antibody

Rabbit Anti-VSIG4 protein 

別名：V-set and immunoglobulin domain-containing protein 4; CRIg; V set and immunoglobulin domain containing 4; Z39IG; VSIG4_HUMAN.                 

來(lái)源：Rabbit

克隆類(lèi)型：Polyclonal

濃度：1mg/ml

亞型：IgG

反應(yīng)：Mouse,Rat (predicted: Human,Cow,Dog)

應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

       IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

理論分子量：33kDa

免疫原：KLH conjugated synthetic peptide derived from human VSIG4 protein

保存：-20℃
保質(zhì)期：1年

產(chǎn)品名稱：Anti-VSIG4 protein antibody

Mouse Anti-VSIG4 protein

別名：V-set and immunoglobulin domain-containing protein 4; CRIg; V set and immunoglobulin domain containing 4; Z39IG; VSIG4_HUMAN.                    

來(lái)源：Mouse

克隆類(lèi)型：Monoclonal

濃度：1mg/ml

亞型：IgG

反應(yīng)：Human

應(yīng)用：WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

       IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

反應(yīng):  Human

理論分子量：33kDa

免疫原：KLH conjugated synthetic peptide derived from human VSIG4  

保存：-20℃
保質(zhì)期：1年

T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 familyrelated protein V-set and Ig domaincontaining 4 (VSIG4). Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th celldependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.